王宪 |
王宪 教授
主要学历:
1976-1980 北京医科大学医疗系学生
1982-1985 北京医科大学病理生理专业 硕士研究生
1986、1－1988、3 美国芝加哥劳约拉大学医学院生理系 访问学者
1990、9－1991、9 美国肯塔基州立大学医学院生理和生物物理系 访问学者
1992.6 获北医大生理专业博士学位 (在职论文博士)
1992.11-1994.8 美国芝加哥劳约拉大学医学院免疫系和生理系 博士后
主要工作经历:
1980.1-1986.1 北京医科大学病理生理教研室助教、讲师
1988.3-至今 北京医科大学第三医院血管医学研究所讲师、副研(92-95)、正研(1995.6至今)、博导(96.6至今), 副所长(98-2006)
2000.3-至今 北京大学基础医学院, 生理学与病理生理学系教授, 主任（2000-2006）. 基础医学院学术委员会副主任，北京大学医学部学术委员会委员
2006．7-至今 北京大学医学部副主任（主管教学），生理学与病理生理学系 副主任
学会成员和社会兼职:
中国生理学会会员、中国病理生理学会会员、中国药理学会会员、美国免疫学会会员、第22届中国生理学会副理事长兼秘书长、<<生理学报>>, <<国外医学>>,<<北京大学学报>>和<<基础医学与临床>>杂志的编委、<<生理科学进展>>的常务编委
获奖情况:
1990年获美国洛克菲勒生物技术专业基金资助
1994年获教委科技成果二等奖(第一完成人)
1994年获卫生部科技成果三等奖(第三完成人)
1994年获国家首届杰出青年科学基金资助
1996年获政府特殊津贴
1996年获光华科技三等奖
1996年获第二届全国中青年医学科技之星
1998年获教育部科技成果一等奖(第一完成人)
1998年获香港求是科技基金会的杰出青年学者奖
1998年获第四届中国青年科学家奖
2000年获教育部和李嘉诚基金会长江学者奖
2003年获得中央组织部等国家六个部颁发的“留学回国人员成就奖”
2004年获国家科技部授予的国家重点基础研究发展计划（973计划）先进个人
2004年获全国优秀博士学位论文指导教师奖
2005 年获北京高校优秀共产党员称号
2005 年获教育部创新团队带头人
2005年获北京大学奖教金的杨芙淸王阳元院士优秀奖
2006年获北京大学医学部“女教职工之星”称号
科研兴趣：
内源性血管活性物质相互作用参与心血管疾病的发生和发展
神经内分泌－免疫系统之间相互作用的机制
心血管疾病的炎症免疫发病机制
发表论文情况:
已发表原著论文140余篇, 其中在SCI杂志上发表论文70篇以上，1988年以来发表的主要论文如下 （*责任作者）:
Daugirdas, J.T., Wang, X., Swanson, V., Agrawal, A. Depressant effect of acetate in isolated cardiac tissue. Cardiovascular Research 1988, 22: 566-570
Daugirdas, J.T., Swanson, V., Islam, S., Nutting, C., Kim, D.D., Wang, X., Fiscus, R.R. Acetate causes endothelium-independent increases in cyclic AMP in rat caudal artery. American Journal of Physiology 1988, 255: H1378-H1383
韩启德、史凤鸾、王宪、汤健.降钙素基因相关肽(CGRP)对大鼠冠状动脉结扎前后的血液动力学作用。北京医科大学学报1988,20:333-336
Wang, X., Fiscus, R.R. Calcitonin gene?related peptide increases cAMP, tension and rate in rat atria. American Journal of Physiology 1989, 256: R421 ? R428
Han, C., Wang, X., Fiscus, R.R., Gu, J., McDonald, J. Changes in cardiac neuropeptide Y after experimental myocardial infarction in rat. Neuroscience Letters 1989, 104: 141 – 146
Xu, D., Wang, X., Wang, J.P., Yuan, Q.X., Fiscus, R.R., Chang, J.K., Tang, J. Calcitonin gene?related peptide (CGRP) in normotensive and spontaneously hypertensive rats. Peptides 1989, 10: 309 – 312
王宪、韩启德.降钙素基因相关肽(CGRP)：一种新发现的有强大心血管作用的神经肽。生理科学1989, 9:1-5
王宪、韩启德、陈明哲.清醒大鼠内毒素休克时血浆CGRP浓度及血管对CGRP反应性的改变. 北京医科大学学报1989,1:19-21
王宪、韩启德、杨丽华、齐鸣、陈明哲. 清醒大鼠内毒素休克时体内降钙素基因相关肽(CGRP)改变的进一步研究. 北京医科大学学报1989, 21：105-107
韩启德、王宪.降钙素基因相关肽引起大鼠尾动脉舒张并使cAMP含量增加. 生理科学1989, 9：28－30
王宪、韩启德、陈明哲.大鼠失血性休克时血浆降钙素基因相关肽的变化。中国循环杂志1989,4:321-323
徐东、王宪、王建平、韩启德、袁其晓、汤健.正常与自发性高血压大鼠的降钙素基因相关肽浓度。中华心血管病杂志1989,17:174-177
Joyce, C.D., Fiscus, R.R., Wang, X., Dries, D.J., Morris, R.C., Prinz, R.A. Calcitonin gene?related peptide levels are elevated in septic patients. Surgery 1990, 108: 1097 – 1101
韩启德、文晓征、王宪、席与萍、陈明哲. 激光烧灼对兔离体主动脉舒张和收缩功能的影响。中国应用生理学杂志1990,6:166－169
韩启德、文晓征、王宪、汤健、陈明哲.降钙素基因相关肽对离体兔脑动脉的舒张作用。北京医科大学学报1990,22:41-43
赵一鸣、韩启德、王宪、陈明哲.CGRP对垂体后叶素和异丙基肾上腺素引起清醒大鼠心电ST段升高的影响。北京医科大学学报1990,22:92
Wang, X, Han, C, Fiscus, R.R. Qi, M, Jones, S.B. Hypotension-and endotoxin-induced alterations in calcitonin gene-related peptide: modulation by dexamethasone. Circulatory Shock 1991; 34:217-223
Wang, X., Han, C., Fiscus, R.R.Calcitonin gene-related peptide (CGRP) causes endothelium-dependent cyclic AMP, cyclic GMP and vasorelaxant responses in rat abdominal aorta.Neuropeptides 1991; 20:115-124
Fiscus, R.R., Zhou, H., Wang, X., Han, C., Ali, S., Joyce, C., Murad, F. Calcitonin gene-related peptide (CGRP)-induced cyclic AMP, cyclic GMP and vasorelaxant responses in rat thoracic aorta are antagonized by blockers of endothelium derived relaxant factor (EDRF). Neuropeptides 1991,20:133-143
韩启德、杨丽华、王宪、陈明哲.兔主动脉粥样硬化后反应性的改变. 中国病理生理杂志 1991,7:7-11
吴皎辉、韩启德、王宪、王涛、陈明哲.大鼠心肌缺血与重灌时α1肾上腺素受体及其亚型的改变. 中国病理生理杂志 1991,7:122-125
王宪、韩启德、杨丽华、陈明哲. 抗炎药能抑制内毒素休克大鼠血浆CGRP浓度的升高. 生理学报 1991,43:410-413
王涛、韩启德、杨丽华、王宪、陈明哲. 神经肽Y对心肌蛋白质合成的影响及其意义. 中国循环杂志 1991,6:354-359(获该杂志全国征文三等奖)
王宪、曹向辉、韩启德、陈明哲、康德宣. 脑血管病患者脑脊液中降钙素基因相关肽(CGRP)浓度的改变. 中华神经精神科杂志 1991,24:133-134
曹向辉、康德宣、杨丽华、王宪、韩启德.脑血管病患者脑脊液神经肽Ｙ浓度的测定及意义. 中华内科杂志 1991,30:429-430
陈咏梅、王宪、韩启德. 激活ATP依赖性钾通道是CGRP舒血管作用的机制之一. 北京医科大学学报 1991,23:362-363
王宪、韩启德、杨丽华.清醒大鼠内毒素休克时血浆和组织中神经肽Y含量的变化. 中国循环杂志 1991,6:586-588
Fedorak, I., Prinz, R., Fiscus, R.R., Wang, X., Chaumont, J.,Chejfec, G., Glisson, S. Plasma calcitonin gene-related peptide (CGRP) and atrial natriuretic peptide (ANP) levels during resection of pheochromocytoma. Surgery 1991, 110:1094-1099
Wang, X., Han, C., Yang, L. Chen, M., Fiscus, R.R. Ibuprofen, indomethacin, and high-dose aspirin, but not low-dose aspirin or imidazole, inhibit CGRP elevations in plasma during endotoxicosis. Annals of the New YorkAcademy of Sciences 1992, 657: 502-504
Fiscus, R.R., Wang, X., Han, C. hCGRP8-37 antagonizes vasodilations and cAMP responses to rat CGRP in rat caudal artery. Annals of the New YorkAcademy of Sciences 1992, 657: 513-515
韩启德、李金玲、陈咏梅、王宪、赵一鸣. 内毒素血症大鼠血管α1肾上腺素受体及其亚型的改变. 北京医科大学学报 1992,24: 161-164
Wang, X., Jones, S.B., Zhou, Z., Han, C., Fiscus, R.R. Calcitonin gene-related peptide (CGRP) and neuropeptide Y (NPY) levels are elevated in plasma and depleted in blood vessels during endotoxin shock in the rat. Circulatory Shock 1992, 36:21-30
Fiscus, R.R., Gross, D.R., Hao, H., Wang, X., Arden, W.A., Maley, R.H., Sulley, R.K. Nomega-nitro-L-arginine blocks the second phase but not the first phase of the endothelium-dependent relaxations induced by substance P in isolated rings of pig carotid artery. Journal of Cardiovascular Pharmacology 1992, 20:S105-S108
Jones, S.B., Wang, Z., Wang, X., Roberts, J.C., Weber, M., Mathews, H.L.Immune cells mediats epinephrine secretion from bovine chromaffin cells in vitro. Life Sciences 1993, 53:PL447-451
Fiscus, R.R., Hao, H., Wang, X., Arden, W.A., Diana, J.N. Nitroglycerin (Exogenous nitric oxide) substitutes for endothelium-derived nitric oxide in potentiation vasorelaxations and cyclic AMP elevations induced by calcitonin gene-related peptide (CGRP) in rat aorta. Neuropeptides 1994, 26:133-144
Hao, H., Fiscus, R.R., Wang, X., Diana, J.N. Nomega-nitro-L-arginine inhibits vasodilations and elevations of both cyclic AMP and cyclic GMP levels in rat aorta induced by calcitonin gene-related peptide (CGRP). Neuropeptides 1994,26:123-131
Wang, X., Fiscus, R.R., Tang, Z., Yang, L., Wu, J., Fan, S., Mathews, H.L. CGRP in the serum of endotoxin treated rats suppresses lymphoproliferation. Brain Behavior, and Immunity 1994, 8:282-292
Arden, W.A., Fiscus, R.R., Wang, X., Yang, L., Maley, R., Nielsen, M., Lanzo, S., Gross, D.R. Elevations in circulating calcitonin gene-related peptise correlated with hemodynamic deterioration during endotoxin shock in pigs. Circulatory Shock 1994, 42:147-153
Arden, W.A., Fiscus, R.R., Wang, X., Maley, R., Lanzo, S., Gross, D.R. Early endotoxic shock results in enhanced vasodilator responses to nitroglycerin but unaltered responses in neuropeptides calcitonin gene-related peptide and substance P. Shock 1994,1:425-431
Wang, X., Han, C., Hones, S.B., Yang, L.,Fiscus, R.R. Calcitonin gene-related peptide release in endotoxicosis may be mediated by prostaglandins. Shock 1995,3:34-39
Wang, X., Fiscus, R.R., Yang, L., Mathews, H.L. Suppression of the functional activity of IL-2 activated lymphocytes by CGRP. Cellular Immunology 1995, 162:105-113
李和旺、王宪、韩启德.细胞内贮存钙释放的机制. 生理科学进展1995,26:209-212
吴中欣、韩启德、白燕、王宪. 机体内环境理化因素对降钙素基因相关肽(CGRP)释放的影响. 生理学报 1995,47:573-579
唐跃明、王宪、韩启德.一氧化氮及其合成酶与心血管疾病（综述）。心血管病学进展1995,16:227-279
邢宇彤、王宪. 免疫系统也合成和释放神经内分泌多肽。生理科学进展 1996, 27:261-264
王宪、吴中欣、唐跃明、韩启德.内毒素对离体大鼠肠系膜动脉降钙素基因相关肽(CGRP)释放的作用。生理学报 1996,48:37-42
王宪、吴中欣、唐跃明、韩启德. 一氧化氮和前列腺素在内毒素引起降钙素基因相关肽释放中的作用。生理学报 1996,48:217-221
王宪、唐跃明、邢宇彤、韩启德. 内毒素引起离体大鼠脊髓降钙素基因相关肽释放。中国药理学与毒理学杂志 1996,10:127-130
Wang, X*., Wu, Z., Tang, Y., Fiscus, R.R., Han, C. Rapid nitric oxide-and prostaglandin-dependent release of calcitonin gene-related peptide (CGRP) triggered by endotoxin in rat mesenteric arterial bed. British Journal Pharmacology 1996,118:2164-2170
王宪、唐跃明、韩启德. 一氧化氮不介导内毒素引起的离体大鼠脊髓释放降钙素基因相关肽。北京医科大学学报 1996,28:249-251
唐跃明、韩启德、孙威、吴中欣、王宪.炎症介质在内毒素引起大鼠肠系膜血管床降钙素基因相关肽释放中的作用。中国应用生理学杂志 1996,12:193-197
吴中欣、唐跃明、韩启德、王宪. 炎症介质对离体大鼠肠系膜动脉降钙素基因相关肽释放的影响。生理学报 1996,48：571－576
唐跃明、韩启德、王宪. 咖啡因引起离体大鼠脊髓降钙素基因相关肽(CGRP)释放。北京大学学报 1996,28: 405-407
冯雁、王宪. 单核/巨噬细胞分泌TNF-a的调控及在老年时的改变。生理科学进展1997,28:249-252
Li, Y., Fiscus, R.R., Wu, J., Yang, L, Wang, X*.. The antiproliferative effects of calcitonin gene-related peptide (CGRP) in different passages of cultured vascular smooth muscle cells. Neuropeptides 1997, 31: 503-509
郭静萱、孙威、邢立愚、王宪.大鼠肠系膜动脉床和脊髓降钙素基因相关肽的老年性改变. 中华心血管病杂志1997, 25：362－366
Wang, X., Fiscus, R.R. Lactic acid potentiates bradykinin- and low pH-induced release of CGRP from rat spinal cord slices. American Journal of Physiology 1997, 273: E92-E98
Feng, Y., Tang, Y., Guo, J., Wang, X*.. Inhibition of LPS-induced TNF-a production by calcitonin gene-related peptide (CGRP) in cultured mouse peritoneal macrophages. Life Sciences1997, 61: PL281-287
邢宇彤、孙兆玉、邢立愚、王宪.大鼠淋巴细胞中存在降钙素基因相关肽(CGRP). 科学通报1997, 42: 2653-2656
唐跃明、韩启德、王宪. 钙离子在内毒素引起大鼠脊髓降钙素基因相关肽(CGRP)释放中的作用。中国科学（C辑）1997，27：378-384
Tang, Y., Han Q., Wang, X*.. The role of calcium in endotoxin-induced release of clcitonin gene-related peptide (CGRP) from rat spinal cord. Science in China (Series C) 1997, 40: 437-442
唐跃明、韩启德、邢宇彤、白燕、王宪.大鼠内毒素血症不同时期降钙素基因相关肽(CGRP)表达和释放的变化。生理学报 1997,49: 160-166
Tang, Y., Han, C., Fiscus, R.R., Wang, X*.. Increase of calcitonin gene-related peptide (CGRP) release and mRNA levels in endotoxic rats. Shock 1997,7: 225-229
王宪.降钙素/降钙素基因相关肽族。陈元方、Yamada，T. 主编的《胃肠肽类激素基础与临床》第22章北京医科大学中国协和医科大学联合出版社1997年，P. 396-406
王宪、孙威、邢立愚、宫海滨. 糖尿病大鼠肠系膜动脉降钙素基因相关肽释放减少以及一氧化氮的作用。生理学报1998, 50: 206－212
Tang, Y., Feng, Y., Wang, X*. Calcitonin gene-related peptide (CGRP) potentiates LPS-induced IL-6 release from mouse peritoneal macrophages. Journal of Neuroimmunology 1998, 84: 207-212
唐跃明、冯雁、郭静萱、王宪.老年大鼠单核/巨噬细胞分泌和表达肿瘤坏死因子增多。中国应用生理学杂志1998,14:272-275
孙威、、唐跃明、王宪.降钙素基因相关肽放射免疫测定中与内毒素交叉免疫的离体实验分析。 生理学报1998,50:444-448
Sun, W., Guo, J., Tang, Y., Wang, X*. Alteration of capsaicin and endotoxin-induced calcitonin gene-related peptide release from mesenteric arterial bed and spinal cord slice in 18-month-old rats. Journal of Neuroscience Research 1998, 53: 385-392
孙威、韩启德、唐跃明、王宪. a2-肾上腺素受体对内毒素引起的大鼠肠系膜动脉床降钙素基因相关肽释放的调节作用。生理学报1998, 50: 227-231
Xing, L., Guo, J., Tang, J. Tang, Y., Wang, X*.Morphological evidence for the location of calcitonin gene-related peptide (CGRP) immunoreactivity in rat lymphocytes. Cell Vision- Journal of Analytical Morphology 1998, 5: 8-12
邢立愚, 邢宇彤, T唐跃明, 郭静萱, 王宪. 大鼠淋巴中降钙素基因相关肽(CGRP)mRNA的表达。生理学报1998, 50: 423-430
Fiscus, R.R., Lu, L., Tu, A.W.K., Hao, H., Yang, L., Wang, X. Brain natriuretic peptide enhances the endothelium-independent cAMP and vasorelaxant responses of calcitonin gene-related peptide in rat aorta. Neuropeptides 1998, 32: 499-509
Wang, X*., Xing, L., Tang, Y., Han, C. Identification and characterization of immunoreactive calcitonin gene-related peptide from lymphocytes of the rat. Journal of Neuroimmunology 1999, 94: 95-102
Tang, Y., Han, C., Wang, X*. Role of nitric oxide and prostaglandins in the potentiating effects of calcitonin gene-related peptide on lipopolysaccharide-induced interleukin-6 release from mouse peritoneal macrophages. Immunology 1999, 96:171-175
Wang, X*., Wang W., Li, Y., Bai, Y., Fiscus, R.R. Mechanism of SNAP potentiating antiproliferative effect of calcitonin gene-related peptide in cultured vascular smooth muscle cells. Journal Molecular Cellular Cardiology 1999, 31:1599-1606
许晖、赵鸣武、王宪. 降钙素基因相关肽释放在大鼠慢性支气管炎发病中的作用。中华医学杂志 1999, 79:385-386
许晖、赵鸣武、王宪. 慢性阻塞性肺疾病和哮喘患者痰中降钙素基因相关肽的变化。中华结核和呼吸杂志 1999, 22:558-561
邢立愚、侯凌飞、孙威、许晖、王宪. 不同类型应激对大鼠神经和免疫源降钙素基因相关肽（CGRP）释放的影响。北京医科大学学报 1999, 31: 528－531
曾辉、陈明哲、郭静萱、王宪.绝经后妇女血清中降钙素基因相关肽水平的变化。北京医科大学学报 1999, 31: 488
张芹、王宪、郭静萱. 幽门螺杆菌感染与冠心病。生理科学进展 1999, 30:41-44
王宪. 降钙素基因相关肽是神经－免疫系统相互调节的介导物质之一。北京医科大学学报 1999, 31: 485－488
曾辉、陈明哲、郭静萱、王宪. 降低雌激素水平对大鼠降钙素基因相关肽合成与释放的影响。中华心血管病杂志2000, 28：61－64。
刘建国、王宪、陈明哲. 一氧化氮和细胞因子之间的相互调节作用。生理科学进展 2000, 31: 61－64
王 望， 王 宪. 降钙素基因相关肽超家族与高血压 心血管病学进展，2000，21：257－262.
Tang, Y., DiPietro, L.D., Feng, Y., Wang, X*.Increase TNF-a and PGI2, but not NO release from macrophages in 18-month-old rats. Mechanisms of Ageing and Development 2000，114：79－88
Liu, J., Chen, M., Wang, X. Calcitonin gene-related peptide inhibits LPS-induced IL-12 release from mouse peritoneal macrophages mediated by cAMP pathway. Immunology 2000, 101:61-67.
Xing, L., Guo, J., Wang, X. *.Induction and expression of beta-calcitonin gene-related peptide (b-CGRP) in lymphocytes and its significance. Journal of Immunology 2000, 165：4359－4366.
李文静、王宪*:心血管细胞保护分子机制研究的新进展。北京大学学报(医学版) 2001, 33:307-311
Liu, J., Chen, M., Wang, X*.Calcitonin gene-related peptide enhanced nitric oxide release and inducible NOS activity and mRNA expression in LPS stimulated mouse peritoneal macrophages. Shock 2001, 16: 64-69.
Sun, C., Chen, M., Mao, J., Wang, X*.Biphasic effects of orchidectomy on calcitonin gene-related peptide synthesis and release. NeuroReport, 2001, 12:3497－3502.
Hou, L., Wang, X*. PKC and PKA mediate LPS-induced release of CGRP in DRG neurons of neonatal rats. Journal Neuroscience Research2001, 66:592－600.
Zhang, Q., Guo, J., Wang, X.*.Effects of homocysteine on murine splenic B lymphocyte proliferation and its signal transduction mechanism. Cardiovascular Research. 2001, 52:328-336
Xing, L., Huo, L., Wang, X*.The comparison of calcitonin gene-related peptide release from rat lymphocytes and dorsal root ganglia neurons. Brain Behavior, and Immunity 2002, 16:17-32
Zhang, Q., Guo, J., Wang, X*.Oxidant stress mechanism of homocysteine potentiating Con A-induced proliferation in murine splenic T lymphocytes. Cardiovascular Research 2002, 53:1035-1042.
Wang, X., Ebong, S.J, Call, D.R., Newcomb, D.E., Bolgos, G.R., Remick, D.G. Calcitonin gene-related peptide partially reverses decreased production of chemokine KC and MIP-2 secretion from murine sepsis. Inflammation 2002, 26:167-174
Wang, W., Sun, C., Wang, X*.Alteration of calcitonin gene-related peptide, acetylcholine and norepinephrine induced vascular responses in gonadectomized rats. Acta Pharmacologica Sinica 2002, 23:985-990
Wang, H., Xing, L., Guo, J., Wang, X*.Production and secretion of calcitonin gene-related peptide from human lymphocytes. Journal of Neuroimmunology 2002, 130: 155-162
朱健健，王宪. 慢性炎症、自身免疫病和动脉粥样硬化。生理科学进展33: 327-331, 2002 (综述).
Sun, W., L. Wang, M. Chen, Wang, X*.Intramuscular transfer of naked calcitonin gene-related peptide prevents autoimmune diabetes induced by multiple low dose streptozotocin in C57BL mice. European Journal Immunology 2003, 33:233-242.
Hou, L., W. Li, Wang, X*.Mechanism of interleulin-1b-induced calcitonin gene-related peptide from DRG neurons of neonatal rats. Journal Neuroscience Research 2003, 73:188-197.
Zeng, X., Remick, D., Wang, X*.Homocysteine induces secretion and expression of chemokine MCP-1 and IL-8 in human monocytes. Circulation Research 2003 93:311-320 with Editorials: 271-273.
Wang, W., X. Wang.*.Alateration of calcitonin gene-related peptide, acetylcholine, and norepinephrine induced vascular responses in ovariectomized rats. Chin J Pharmacol Toxicol,（中国药理学与毒理学杂志）2003, 17:338-344.
Wang, L.，Sun, W.，Chen, M，Wang, X*.Intramuscular injection of naked plasmid DNA encoding human preproinsulin gene in STZ-diabetes mice results in a significant reduction of blood glucose level. Acta Physiologica Sinica（生理学报）2003, 55:641-647 .
She, F., Sun, W., Mao, J., Wang, X.*Calcitonin gene-related peptide gene therapy suppresses reactive oxygen species in the pancreas and prevents mice from autoimmune diabetes. Acta Physiologica Sinica（生理学报）, 2003，55:625-632
Qin, X., L. Hou, X. Wang.*Lipopolysaccharide evoked peptide release by calcium-induced calcium release. NeuroReport, 2004;15:1003-1006
Wang, W., W. Sun，X. Wang*.Intramuscular gene transfer of CGRP inhibits neointimal hyperplasia after balloon injury in the rat abdominal aorta.Am J. Physiol Heart Circ Physiol, 2004, 287: H1582-H1589.
Zeng, X., D. G. Remick, X. Wang*. Homocysteine induces the secretion of monocyte chemoattractant protein-1 and interleukin–8 in cultured human whole blood. Acta Pharmocol Sinica, 2004, 25:1419-1425
Wang, G., J. Wei, Y. Guan, J. Mao, X. Wang*.Peroxisome proliferators-activated receptor-γ agonist rosiglitazone reduces clinical inflammatory responses in type 2 diabetes with coronary artery disease after coronary angioplasty. Metabolism, 2005,54:590-597
Wang, G., J. Mao, X. Wang. F. Zhang. Effect of homocysteine on plaque formation and oxidative stress in patients with acute coronary syndromes. Chin Med J, 2004;117:1650-1654
金楠，王宪.过氧化物酶体增殖物激活受体与动脉粥样硬化. 生理科学进展, 2004，35:13-18.(综述)
谢良麒，王宪. C反应蛋白与动脉粥样硬化。生理科学进展, 2004，35:113-118. (综述)
贾凌云，王宪.蛋白质组学技术及其在心血管疾病中的应用。生理科学进展，2004，35: 237-239. (综述)
Li, W, L. Hou, Z. Hua, X. Wang*. Interleukin-1β induces β-calcitonin gene-related peptide secretion in human type II alveolar epithelial cells. FASEB J, 2004;18:1603-1605, fj.04-1737
Wang, G., J. Mao, X. Yang, X. Wang*.Folic acid reverses hyper-responsiveness of LPS-induced chemokine secretion from monocytes in patients with hyperhomocysteinemia. Atherosclerosis, 2005，179：395-402
Zeng, X., Y. Guan, D.G. Remick, X. Wang*.Signal pathways underlying homocysteine-induced production of MCP-1 and IL-8 in cultured human whole blood. Acta Pharmocol Sin, 2005, 26:85-91.
李文静，王宪.炎症诱导免疫源性神经肽分泌及其抗炎意义。国外医学-生理、病理科学与临床分册。2004, 24:487-491.
Wang, W., L. Jia, T. Wang, W. Sun, S. Wu, X. Wang*. Endogenous calcitonine gene-related peptide protects human alveolar cells through protein kinase Ce and heat shock protein. J Biol Chem, 2005, 280:20325-20330
Xie, L., L. Chang, Y. Guan，X. Wang*. C-Reactive Protein augments interleukin-8 production in human blood monocytes. J Cardiovas Pharmocal，2005, 46:690-696.
Qin, X., Y. Wan, X. Wang*.CCL2 and CXCL1 trigger calcitonin gene-related peptide release by exciting primary nociceptive neurons. J Neurosci Res 2005; 82:51-62.
Wu, J., Y. Zhang, N. Wang, L. Davis, G.. Yang, X. Wang, Y. Zhu, M.D. Breyer, Y. Guan. Liver X receptor-mediates cholesterol efflux in glomerular mesangial cells. Am J Physiol Renal Physiol, 2004; 287:F886-895
Zeng, L., L. Liao, Y. Liu, T. Lee, M. Zhu, X. Wang, M. Stemerman, Y. Zhu,
J.Y.-J. Shyy. Sterol-responsive Element-binding Protein (SREBP) 2 Down-regulates ATP-binding Cassette Transporter A1 in Vascular Endothelial Cells. J. Biol. Chem., 2004;279: 48801-48807
Ouyang, K., H. Zheng, X. Qin, C. Zhang, D. Yang, X. Wang, C. Wu,Z. Zhou, H. Cheng. Ca2笔sparks and secretion in dorsal root ganglion neurons. Proc Natl AcadSci USA 2005, 102:12259-12264
Zhu,Y.H.,X. Wang*..Overexpression of heart-shock protein 20 in rat heart myogenic cell confers protection against stimulated ischemia/reperfusion injury. Acta Pharmocol Sin, 2005, 26:1076-80
Zhu, Y., H. Liao, X. Xie, Y. Yuan, TS Lee, N. Wang, X. Wang, JY Shyy, MB Stemerman. Oxidized LDL downregulates ATP-bingding cassette transporter-1 in human vascular endothelial cells via inhibiting liver X receptor (LXR). Cardiovasc. Res, 2005, 68：425-432 with Editorials, 2005, 68:353-354
Zhu, Y.H., T. Ma, X. Wang*.. Gene transfer of heat-shock protein 20 protects against ischemia/reperfusion injury in rat heart. Acta Pharmocol Sin, 2005, 1193-1200
Sun, W.,G. Wang，Z. Zhang, X. Zeng, X. Wang*.. Chemokine RANTES is upregulated in monocytes from patients with hyperhomocysteinemia. Acta Physiologica Sin, 2005, 26:1317-1321.
Jiang, H., X. Wang, L. Fang, C. Tang, Y. Zhu, X. Wang*. Upregulation of aldose reductase by homocysteine in type II alveolar epithelial cells. BBRC, 2005, 337:1084-1091
Dai, J., W. Li, L. Chang, Z. Zhang, C. Tang, N. Wang, Y. Zhu, X. Wang*. Role of redox factor-1 in hyperhomocysteinemia accelerated atherosclerosis. Free Radical Bio Med, 2006, 41:1566-1577.
Li, W., T. Wang, C. Ma, T. Xiong, Y. Zhu, X. Wang*. Calcitonin gene-related peptide inhibits interleukin1-b-induced endogenous monocyte chemoattractant protein-1 secretion in human type II alveolar epithelial cell. Am J Physiol Cell Physiol. 2006, 291: C456-65.
Zhang, Y., B. Xiang, Y. Li, Y. Wang, X. Wang, Y. Wang, L. Wu, G. Yu. Expression and characteristics of vanilloid receptor 1 in the rabbit submandibular gland. BBRC, 2006, 345: 467-473.
Li, W., T. Wang, X. Wang*.Calcitonin gene-related peptide inhibits interleukin1-b-induced interleukin-8 secretion in human type II alveolar epithelial cell. Acta Pharmocol Sin, 2006, 27: 1340-1345.
Wang T., Chen Z., Wang X., Shyy J. Y-J., Zhu Y. Cholesterol Loading Increases the Translocation of ATP Synthase β Chain into Membrane Caveolae in Vascular Endothelial Cells. BBA – Mol Cell Biol L, 2006, 1761:1182-1190.
Chen, M., W. Li, N. Wang, Y. Zhu* and X. Wang*. ROS and NF-kB but not LXR mediate IL-1b signaling for the downregulation of ATP-binding cassette transporter A1. Am J Physiol Cell Physiol. 2007，292:C1493-C1501.
He R., A. Qu, J. Mao, X. Wang*, W. Sun. Synergistic proliferation induced by insulin and glycated serum albumin in rat vascular smooth muscle cellsActa Physiol Sin 2007，59：1-7.
Yi Quan Y., J. Du, X. Wang. High Glucose Stimulates GRO Secretion from Rat Microglia via ROS, PKC and NF-кB pathways. J Neurosci Res, 2007 (In press).
Chang, L*., Z. Zhang*, W. Li, J. Dai, Y. Guan, X. Wang.Liver-X-receptor activator prevents the homocysteine-induced production of IgG antibody from murine B lymphocytes via ROS-NF-kB pathway. BBRC, 2007， 357：772-8. *These authors contributed to this work equally.
Li, W., S. Zheng, C. Tang, Y. Zhu, X. Wang..JNK-AP-1 pathway involved in interleukin-1b-induced calcitonin gene-related peptide secretion in human type II alveolar epithelial cells. Peptides 2007, 28:1252-1259.
Jia, L., W. Wang, W. Zhen, M. Xu, X. Shen, Y. Zhu, X. Wang.Thioredoxin is a novel mediator of calreticulin in protecting human type II alveolar epithelial cells against ischemic injury. Am J Physiol Cell Physiol, 2007 (In press).
冯娟， 王宪。调节性 T 细胞在动脉粥样硬化发病中的作用。生理科学进展, 2007, 38:58-61 (综述)..
Jie Yu*, Nan Jin*, Guang Wang, Fuchun Zhang, Jieming Mao, Xian Wang.PPAR-γ agonist improved arterial stiffness in type 2 diabetes patients with coronary artery disease. Metabolism, 2007，56：1396-1401 *These authors contributed to this work equally.
王笑菲,王宪*.调节性 T 细胞和1型糖尿病.国际病理科学与临床杂志 .2007,27:169-174.综述
Dai, J., X. Wang. Immunoregulatory effects of homocysteine on cardiovascular diseases. 生理学报，2007，59: 5 (特邀综述，Epub ahead of print.).
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Fiscus, R.R., X. Wang, and H. Hao. hCGRP8-37, antagonizes vasodilations and cyclic AMP responses to rat calcitonin gene?related peptide (rCGRP) in rat caudal artery. In: Calcitonin Gene?Related Peptide. The First Decade of a Novel Pleiotropic Neuropeptide, ed. Y. Tache, P. Holzer and M.G. Rosenfels, Annals of the New York Academe of Sciences Vol. 657, New York, Chapter 66, p 513?515, 1992.
Wang, X., Calcitonin/Calcitonin gene-related peptide. In textbook of gastrointestinal peptide hormones, basic and clinical aspects, ed. Y. Chen and T. Yamada. PUMC and BMU Joint Press, p. 396-406, 1997.
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王宪：降钙素基因相关肽与休克。罗正曜、金惠铭、唐朝枢主编的《休克学》第5章 第三节，天津科学技术出版社出版 2001年，P. 235－243 |
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